Turkey Biscuit Bake

This delightful, creamy casserole combines the savory flavors of cream of chicken soup, succulent leftover or shredded turkey, a medley of vegetables, and a generous amount of cheese. Our Leftover Turkey and Biscuit Casserole is incredibly easy to make and bursting with flavor! It’s the perfect way to repurpose those holiday leftovers into a comforting and satisfying meal.

Do you want to skip straight to the recipe? Use the “Jump to Recipe” button located at the top of this page for quick access to the ingredients and instructions. If you’d like to learn more about the preparation, please read on!

At Sweet C’s, we believe in providing plenty of helpful tips within our recipes. Our goal is to empower even beginner home cooks to feel confident in the kitchen by understanding the “why” behind each ingredient and step. Cooking should be enjoyable, not intimidating!

Table of Contents

• How to Make Leftover Turkey and Biscuit Casserole
• Tips and Tricks for the Perfect Casserole
• Leftover Turkey and Biscuit Casserole Recipe

How to Make Leftover Turkey and Biscuit Casserole

This casserole recipe is incredibly easy to customize. You can use any type of canned condensed soup or even make your own condensed soup from scratch. Feel free to use whatever vegetables you have on hand, whether they’re leftovers or frozen! This recipe is very forgiving.

Our Slow Cooker Shredded Turkey is absolutely divine in this casserole. The slow cooking process ensures the turkey is tender and flavorful, making it the perfect addition to this comforting dish.

Leftover Turkey and Biscuit Casserole Ingredients

To create this delicious casserole, you’ll need the following ingredients:

• 2 cups cooked turkey, shredded or diced – Adds a hearty protein base. Shredding provides a creamier texture, while dicing offers chunkier bites.
• 2 cups frozen mixed vegetables – Introduces color, sweetness, essential nutrients, and varied textures. A mix of peas, carrots, corn, and green beans keeps the casserole balanced and satisfying.
• 1 (10.5-oz) can cream of chicken soup – Serves as the creamy and savory foundation, binding all the ingredients together and contributing salt, umami, and thickening properties.
• ½ cup milk – Thins the soup slightly, creating a smooth, pourable sauce that adds a mild creaminess without weighing down the dish.
• 2 tablespoons melted butter – Enhances richness and overall flavor, helping to soften and coat the vegetables and turkey.
• 1½ cups shredded cheddar cheese (1 cup in the filling, ½ cup on top) – Provides melty, savory, cheesy comfort. The top layer creates a golden, gooey crust, while the filling layer makes the casserole extra creamy.
• 1 can refrigerated biscuits (8-count) – Offers a fluffy, buttery, and satisfying bread topping that puffs up and turns golden brown, giving the casserole a pot-pie feel without the effort of making a crust from scratch.
• Salt & pepper to taste – Crucial for balancing the creamy flavors and enhancing the overall taste of the turkey and vegetables.
• Optional: garlic powder, onion powder, dried thyme, paprika – These deepen the flavor profile. Garlic and onion powder add a savory warmth, thyme contributes an herbal depth, and paprika provides color and a subtle smoky note.

Steps to Make Leftover Turkey and Biscuit Casserole

Here’s a step-by-step guide to assembling your casserole:

Mix Turkey, Vegetables, and Soup

In a large bowl, gently combine the shredded turkey, mixed frozen vegetables, and cream of chicken soup. Ensure all ingredients are evenly distributed.

Mix in Cheese

Add one cup of the shredded cheese to the turkey mixture. Stir well to incorporate the cheese throughout the filling, creating a rich and cheesy base.

Top with Biscuits

Transfer the turkey and vegetable mixture to a greased casserole dish or skillet. Open the can of biscuits and cut or tear each biscuit into smaller pieces. Arrange the biscuit pieces evenly over the top of the turkey and soup base.

Bake

Bake the casserole at 350°F (175°C). Initially, cover the dish with foil or a lid and bake for 20 minutes. Then, remove the cover and continue baking for another 20-30 minutes, or until the casserole is bubbly and the biscuit dough is golden brown and cooked through.

Tips and Tricks to Perfect Your Leftover Turkey and Biscuit Casserole

Want to take your Turkey and Biscuit Casserole to the next level? Here are some expert tips and tricks:

• Cut the biscuits into quarters to ensure they bake evenly and thoroughly. Whole biscuits often remain doughy in the middle.
• Use freshly shredded cheddar cheese if possible. It melts more smoothly and creates a creamier texture than pre-shredded bagged cheese.
• Warm the milk slightly before mixing it with the cream of chicken soup for a smoother sauce consistency.
• Season the filling generously before adding the biscuits. The biscuit topping can mellow the flavors, so ensure the base tastes fantastic on its own.
• Add a pinch of garlic powder, onion powder, and dried thyme, even if you don’t typically season casseroles heavily. These spices add savory depth and complexity.
• Thaw the frozen vegetables for 10–15 minutes or rinse them under cool water to remove excess ice. This prevents the casserole from becoming watery.
• Stir some cheese into the filling and sprinkle some on top for the best texture combination – creamy inside, golden and bubbly outside.
• Brush the biscuits with a little melted butter before baking to promote beautiful browning and a richer flavor.
• Bake the casserole on the lower-middle rack of the oven to ensure the biscuits brown without overcooking the bottom of the casserole.
• Cover the casserole with foil if the biscuits brown too quickly. This will protect the topping while allowing the filling to cook through.
• Let the casserole rest for 5 minutes before serving. This allows the filling to thicken slightly, making it easier to scoop and serve.
• Swap out Grands biscuits for flaky-layer biscuits if you prefer a pull-apart, buttery layered topping.
• Add a handful of cooked bacon or ham to the filling for even more depth and smoky flavor.
• Don’t skip the pepper! The creamy base benefits from a touch of sharpness to maintain a balanced flavor profile.
• Serve the casserole with a simple side salad or roasted vegetables to complement the richness of the dish.

FAQs for Turkey Biscuit Casserole

Can I use chicken instead of turkey?

Yes! Rotisserie chicken or any leftover cooked chicken works perfectly and tastes equally delicious in this casserole.

Do I need to thaw the frozen vegetables first?

It’s not essential, but partially thawing or rinsing the vegetables helps reduce excess moisture in the casserole.

Can I use a different cream soup?

Absolutely! Cream of mushroom, cream of celery, or cream of turkey soup are all excellent alternatives.

Can I substitute the Grands biscuits?

Yes, you can use flaky-layer biscuits, homemade biscuit dough, or even puff pastry for a different twist.

Why are my biscuits doughy in the middle?

The biscuits were likely too large. Quartering the biscuits helps them bake through evenly. You can also extend the baking time by 5–10 minutes if needed.

Can I add more vegetables?

Definitely! Corn, green beans, peas, sautéed mushrooms, or broccoli florets are all great additions.

Can I make this casserole ahead of time?

You can assemble the filling in advance, but add the biscuits right before baking to ensure they stay crisp and rise properly.

Does this freeze well?

The filling freezes beautifully, but the biscuits do not. Freeze the filling separately and top with fresh biscuits when baking.

Can I make it extra cheesy?

Absolutely! Add extra cheddar cheese to the filling or sprinkle a full cup on top for a cheesier finish.

What size pan should I use?

A 9×13 inch casserole dish is ideal, but any similar-sized baking dish will work.

How can I make it lighter?

Use low-fat milk, reduced-fat cream of chicken soup, and half the amount of cheese. You can also reduce the number of biscuit pieces used.

How can I make it spicier?

Add paprika, crushed red pepper flakes, diced jalapeños, or use pepper jack cheese for a spicy kick.

What to Serve With Turkey Biscuit Casserole

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